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Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema

NCT00829855 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 51

Last updated 2013-03-05

No results posted yet for this study

Summary

Acute cardiogenic pulmonary edema (ACPE), one of the most severe forms of acute heart failure, represents 5% of hospital admissions. One of the most frequent phenomena encountered during ACPE is hypertensive crisis (hypertensive ACPE) but the mechanisms and causes of hypertensive ACPE are insufficiently understood. Few studies have evaluated the cardiac function during hypertensive ACPE, and these studies used only conventional echocardiography methods. New methods of evaluation of cardiac function in hypertensive ACPE (such as Tissue Doppler imaging) have not been used.

The objectives of this study are to evaluate presence and role of the following potential mechanisms of hypertensive ACPE: 1. acute myocardial dysfunction (systolic and diastolic); 2. silent transient myocardial ischemia; 3. acute mechanical left ventricular dyssynchrony; 4. dynamic mitral regurgitation; 5. inter-ventricular interaction. Conventional and Tissue Doppler echocardiography will be used to assess cardiac function.

Conditions

Sponsors & Collaborators

  • Ministry of Education, Research, Youth and Sport, Romania

    collaborator OTHER

  • Carol Davila University of Medicine and Pharmacy

    lead OTHER

Principal Investigators

  • Mircea Cinteza, MD, PhD · University of Medicine and Pharmacy "Carol Davila" Bucharest

  • Dragos Vinereanu, MD, PhD · University of Medicine and Pharmacy "Carol Davila" Bucharest

  • Andrei D Margulescu, MD · University of Medicine and Pharmacy "Carol Davila" Bucharest

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2009-05-31
Completion
2009-05-31

Countries

  • Romania

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00829855 on ClinicalTrials.gov