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Obstructive Sleep Apnea and Acute Myocardial Infarction and the Role of Continuous Positive Airway Pressure (CPAP)Treatment

NCT00821210 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2010-12-01

No results posted yet for this study

Summary

Specific Aim

1. To determine the prevalence of OSA in patients of first-time AMI in acute phase By screening patients of first-time, single-vessel disease, Killip I AMI, and successful revascularization
2. To determine the impact of CPAP treatment on the prognosis of AMI Using sham CPAP as the optimal placebo, we conduct this randomized, double-blind, placebo controlled trial to assess the 12-week CPAP effect in moderate-severe OSA patients.
3. To determine how the OSA affects patients with MI in acute and chronic phase and vice versa, which is dissected from mechanical basis and molecular basis By comparing the clinical parameters of AMI patients without OSA (AHI\<5/hr), mild OSA (5 \< AHI \<15), moderate OSA (15\<AHI\<30) and severe OSA5 (AHI\>30/hr), and before and after CPAP treatment, we can determine the interaction between OSA and AMI.

Conditions

  • Sleep Apnea, Obstructive
  • Acute Myocardial Infarction

Interventions

DEVICE

Sham CPAP

CPAP with pressure of 3cm H2O

DEVICE

CPAP of optimal pressure

CPAP of optimal pressure

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Chong-Jen Yu, M.D. · National Taiwan University Hospital

  • Peilin Lee, M.D. · National Taiwan University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2010-01-31
Completion
2010-11-30

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00821210 on ClinicalTrials.gov