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Metastatic Colorectal Cancer: Treatment Response With Dynamic Contrast MRI

NCT00820456 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2023-08-01

No results posted yet for this study

Summary

The objectives for this study include:

* Testing a unique way of imaging people with colorectal cancer and other cancers that has spread to the liver using magnetic resonance imaging (MRI);
* Seeing if the MRI process can be used across multiple imaging platforms;
* Determining whether the results of the imaging can be reproduced;
* Reviewing how MRI results relate to cancer response to combination therapy and to clinical endpoints.

Conditions

  • Colorectal Neoplasm
  • Hepatic Neoplasm

Interventions

OTHER

DCE-MRI

Participants will receive two (2) dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) prior to chemotherapy and one (1) DCE-MRI after the first cycle of chemotherapy. Participants will be followed for up to 2 years after the initiation of chemotherapy or until disease progression.

Sponsors & Collaborators

  • Pennsylvania Department of Health

    collaborator OTHER_GOV

  • American College of Radiology

    lead OTHER

Principal Investigators

  • Mark Rosen, MD, PhD · University of Pennsylvania

  • Larry Dougherty, PhD · University of Pennsylvania

  • Donald Mitchell, MD · Thomas Jefferson University

  • Peter J O'Dwyer, MD · University of Pennsylvania

  • Michael D Feldman, MD, PhD · University of Pennsylvania

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-04-30
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00820456 on ClinicalTrials.gov