A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)

Summary

This is a randomized, controlled clinical trial of inactivated negative ion generation or light-emitting photodiode therapy for Seasonal Affective Disorder (SAD, winter depression), for subjects with a DSM IV diagnosis of Major Depression, with Seasonal Pattern, Winter type, to examine efficacy of treatments for this condition. The trial has a 1 week baseline phase and a 4 week treatment phase.

Conditions

• Seasonal Affective Disorder

Interventions

DEVICE

Negative Ion Generator

Equivalent exposure to inactivated Negative Ion Generator

DEVICE

Light-emitting Photodiode light treatment device

Light-emitting Photodiode light treatment device, used for 30 min before 8 am

Sponsors & Collaborators

• The Litebook Company Ltd.

  collaborator INDUSTRY

• University of British Columbia

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• Harvard University

  collaborator OTHER

• University of Toronto

  collaborator OTHER

• Clinical Associates Research, Maryland

  collaborator NETWORK

• Dalhousie University

  collaborator OTHER

• Yale University

  lead OTHER

Principal Investigators

• Paul Desan, MD, PhD · Yale University

• Raymond Lam, MD · University of British Columbia, Vancouver, Canada

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2008-12-31

Primary Completion

2010-04-30

Completion

2010-04-30

Countries

• United States
• Canada
• Netherlands

Study Locations