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Dose, Effects and Characteristics of Pilocarpine

NCT00803803 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 37

Last updated 2016-11-22

No results posted yet for this study

Summary

The purpose of this investigation, in which pilocarpine was given in repeated doses, was to evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on intraocular pressure. Part II -the effects on intraocular pressure of glaucomatous patients to pilocarpine 2% when given once, twice and four daily. In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Conditions

  • Open-angle Glaucoma

Interventions

DRUG

Pilocarpine Concentration

Varying concentration 0.5 to 8%

DRUG

Pilocarpine Frequency

1 to 4 times daily

Sponsors & Collaborators

  • Wills Eye

    lead OTHER

Principal Investigators

  • George L Spaeth, MD · Wills Eye Glaucoma Service

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1978-08-31
Primary Completion
1979-08-31
Completion
1979-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00803803 on ClinicalTrials.gov