Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness
NCT00793741 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 19
Last updated 2018-01-18
Summary
The purpose of this study is to determine whether islet transplantation alters brain glucose concentrations in patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness when compared to that measured prior to transplant in the same subjects.
Conditions
- Type 1 Diabetes
- Hypoglycemia Unawareness
Interventions
- DRUG
-
somatostatin
Somatostatin may be used to suppress endogenous insulin secretion
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Elizabeth R Seaquist, MD · University of Minnesota
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2007-12-31
- Primary Completion
- 2017-03-31
- Completion
- 2017-03-31
Countries
- United States
Study Locations
More Related Trials
-
Dose-Exposure-Response in Type 1 Diabetes Mellitus
NCT00368394 ·Status: COMPLETED ·Phase: PHASE1
-
IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase
NCT04028960 ·Status: TERMINATED ·Phase: PHASE2
-
GPR119 Agonist for Hypoglycemia in Type 1 Diabetes
NCT04432090 ·Status: COMPLETED ·Phase: PHASE2
-
Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus
NCT00943787 ·Status: COMPLETED ·Phase: NA
-
A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetes
NCT04585776 ·Status: COMPLETED ·Phase: PHASE2
-
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
NCT03746769 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Effects of Pulsatile Intravenous Insulin Delivery on Hypoglycemic Unawareness
NCT01029639 ·Status: WITHDRAWN ·Phase: PHASE2/PHASE3
-
Feasibility Study Assessing the Ability of an Insulin Pump-controlling Algorithm to Minimize Hypoglycemia
NCT01919385 ·Status: COMPLETED ·Phase: PHASE1
-
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
NCT01823406 ·Status: COMPLETED ·Phase: NA
-
Closed Loop Insulin Pump Therapy After Islet Auto-Transplantation
NCT01945138 ·Status: COMPLETED ·Phase: NA
-
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
NCT04614168 ·Status: COMPLETED ·Phase: NA
-
Feasibility Study Assessing The Ability Of An Insulin Pump-Controlling Algorithm To Minimize Hypoglycemia And Hyperglycemia In Patients With Type 1 Diabetes In A Clinical Research Setting
NCT01401751 ·Status: COMPLETED ·Phase: NA
-
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
NCT05095259 ·Status: UNKNOWN ·Phase: NA
-
Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia
NCT02411578 ·Status: COMPLETED ·Phase: PHASE2
-
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
NCT03349489 ·Status: UNKNOWN ·Phase: NA
-
Knee Steroid Injection and Blood Sugar Signatur
NCT04317404 ·Status: COMPLETED
-
Examining the Effects of Neuromodulation on Glucose Metabolism in Type 2 Diabetes
NCT02130401 ·Status: TERMINATED ·Phase: NA
-
Long Term Glucose Metabolism in Conservatively Treated Patients With Congenital Hyperinsulinism
NCT01819584 ·Status: UNKNOWN
-
Glycaemic Load and Pre-meal Insulin Doses in Type 1 Diabetes Patients
NCT01978704 ·Status: COMPLETED ·Phase: NA
-
Brain Ketone Metabolism in Type 1 Diabetes
NCT02471040 ·Status: COMPLETED ·Phase: PHASE1
-
Prevention of Severe Hypoglycemia in Type 1 Diabetes
NCT00360984 ·Status: COMPLETED ·Phase: PHASE4
-
Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia
NCT02700048 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Hypoglycemia Counterregulation and Symptom Perception With Insulin Detemir
NCT00490893 ·Status: TERMINATED ·Phase: PHASE4
-
Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects
NCT03034226 ·Status: COMPLETED ·Phase: NA
-
Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
NCT02855307 ·Status: COMPLETED ·Phase: PHASE2