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Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections

NCT00774098 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2010-04-01

No results posted yet for this study

Summary

We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.

Conditions

  • Liver Function

Interventions

DRUG

dextrose 10% (D10W ®) infusion

Started at 8pm the day before surgery until the procedure begins

DRUG

hyperinsulinemic normoglycemic clamp

Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively

DIETARY_SUPPLEMENT

high calorie diet 35 kcal/kg

High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery

DRUG

Intravenous normal saline (NS 0.9)

Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output

Sponsors & Collaborators

  • McGill University Health Centre/Research Institute of the McGill University Health Centre

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2009-09-30
Completion
2009-09-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00774098 on ClinicalTrials.gov