HCT Versus CT in Elderly AML

Summary

A study comparing conventional chemotherapy to low dose total body irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors as consolidation therapy for older Patients with AML in first Complete Remission.

Conditions

• Acute Myeloid Leukemia

Interventions

PROCEDURE

hematopoietic cell transplantation

low dose total body irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors

DRUG

Non-Transplant treatment approach for consolidation

Patients will receive the treatment that would be otherwise applied at the local institution. The consolidation or maintenance therapy is according to the study group protocol.

Sponsors & Collaborators

• Acute Leukemia French Association

  collaborator OTHER

• Grupo Cooperativo de Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias

  collaborator OTHER

• European Organisation for Research and Treatment of Cancer - EORTC

  collaborator NETWORK

• French Innovative Leukemia Organisation

  collaborator OTHER

• HOVON - Dutch Haemato-Oncology Association

  collaborator OTHER

• East German Study Group of Hematology and Oncology (OSHO)

  collaborator UNKNOWN

• Swiss Cancer Institute

  collaborator OTHER

• European Society for Blood and Marrow Transplantation

  lead NETWORK

Principal Investigators

• Dietger Niederwieser, Prof · EBMT and OSHO

• Bob Löwenberg, Prof · Stichting Hemato-Oncologie voor Volwassenen Nederland

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-01-31

Primary Completion

2020-12-31

Completion

2020-12-31

Countries

• Australia
• Austria
• Belgium
• France
• Germany
• Netherlands
• Switzerland

Study Locations