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Vasopressin, Epinephrine, and Steroids for Cardiac Arrest

NCT00729794 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2016-11-21

No results posted yet for this study

Summary

The simultaneous activation of adrenergic and vasopressin receptors, in conjunction with a potential steroid-mediated enhancement of the vascular reactivity to epinephrine may have beneficial effects in patients with cardiac arrest. This hypothesis is supported by the single-center results of NCT 00411879. The investigators intend to either refute or provide definitive evidence supporting this hypothesis (and its generalizability) by conducting the present multicenter, randomized, controlled clinical trial of in hospital cardiac arrest.

Conditions

  • Cardiac Arrest

Interventions

DRUG

Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone

Combination Treatment Administration of vasopressin, epinephrine, and methylprednisolone during CPR, and of stress dose hydrocortisone after CPR

DRUG

Standard CPR Protocol with Epinephrine and two Placebos

Patients receive advanced life support according to the Guidelines for Resuscitation 2005

Sponsors & Collaborators

  • University of Thessaly

    collaborator OTHER

  • University of Athens

    lead OTHER

Principal Investigators

  • Spyros D Mentzelopoulos, MD, PhD · University of Athens Medical School, Athens, Greece

  • Spyros G Zakynthinos, MD, PhD · University of Athens Medical School, Athens, Greece

  • Charis Roussos, MD, PhD · University of Athens Medical School, Athens, Greece

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-09-30
Primary Completion
2010-11-30
Completion
2010-11-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00729794 on ClinicalTrials.gov