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Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest

NCT00411879 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2016-01-12

No results posted yet for this study

Summary

A randomized controlled trial did not show benefit of vasopressin versus epinephrine in inhospital cardiac arrest. Preceding laboratory data suggest that combined vasopressin and epinephrine ensure long-term survival and neurologic recovery. Also, postresuscitation abnormalities mimic severe sepsis. The investigators hypothesized that combined vasopressin and epinephrine during cardiopulmonary resuscitation (CPR), and steroid supplementation during and after (when required) CPR may improve survival in cardiac arrest.

Conditions

  • Heart Arrest

Interventions

DRUG

Vasopressin, Epinephrine, and Steroids

During resuscitation, study group patients receive vasopresssin \[20 IU IV maximum dose = 100 IU\] and methylprednisolone (40 mg IV). Epinephrine is given to both groups according to guidelines for resuscitation 2005. In the study group, postresuscitation shock is treated with stress-dose hydrocortisone.

DRUG

Placebo, Epinephrine, Placebo

Epinephrine is given to both groups according to guidelines for resuscitation 2005. Control group patients receive placebo instead of vasopressin and steroids.

Sponsors & Collaborators

  • University of Athens

    lead OTHER

Principal Investigators

  • Spyros D Mentzelopoulos, Lecturer · First Department of Intensive Care Medicine, Univerisy of Athens Medical School

  • Charis Roussos, Professor · First Department of Intensive Care Medicine, Univerisy of Athens Medical School

  • Spyros G Zakynthinos, As Professor · First Department of Intensive Care Medicine, Univerisy of Athens Medical School

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-06-30
Primary Completion
2007-04-30
Completion
2007-04-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00411879 on ClinicalTrials.gov