Sorafenib in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
NCT00727532 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9
Last updated 2019-05-03
Summary
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving sorafenib before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
PURPOSE: This clinical trial is studying how well sorafenib works in treating patients with locally advanced or metastatic kidney cancer.
Conditions
- Hereditary Clear Cell Renal Cell Carcinoma
- Kidney Cancer
Interventions
- DRUG
-
400mg by mouth twice daily for 28 consecutive days
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH - lead OTHER
Principal Investigators
-
Timothy M. Kuzel, MD · Robert H. Lurie Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 120 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-07-31
- Primary Completion
- 2011-10-31
- Completion
- 2013-09-30
Countries
- United States
Study Locations
More Related Trials
-
Safety and Toxicity Study of Sorafenib in Patients With Kidney Cancer
NCT00854620 ·Status: COMPLETED ·Phase: PHASE2
-
Treatment Protocol for the Use of Sorafenib in Patients With Advanced Renal Cell Carcinoma
NCT00111020 ·Status: COMPLETED ·Phase: PHASE3
-
A Multi-Center, Non-Controlled Clinical Study of Sorafenib Adjuvant Therapy in Advanced Renal-Cell Carcinoma
NCT01041482 ·Status: UNKNOWN ·Phase: PHASE2
-
Randomized Study of Sorafenib Dose Escalation in Patients With Previously Untreated Metastatic Renal Cell Carcinoma
NCT00557830 ·Status: TERMINATED ·Phase: PHASE2
-
Safety and Toxicity Study of Sorafenib in Patients With Kidney Cancer
NCT00445042 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib as Neoadjuvant Therapy Before Cytoreductive Nephrectomy in Patients With Metastatic Renal Cell Carcinoma
NCT01982097 ·Status: COMPLETED
-
Sorafenib in Treating Patients Undergoing Surgery for Stage II, Stage III, or Stage IV Kidney Cancer
NCT00405366 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Phase III Study of Sorafenib in Patients With Renal Cell Carcinoma (RCC)
NCT00586105 ·Status: COMPLETED ·Phase: PHASE3
-
Sorafenib Dose Escalation in Renal Cell Carcinoma
NCT00618982 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium
NCT00112905 ·Status: TERMINATED ·Phase: PHASE2
-
Pre-operative Administration of Sorafenib in Patients With Metastatic Renal Cell Carcinoma Undergoing Kidney Removal
NCT00480389 ·Status: COMPLETED ·Phase: PHASE2
-
Stereotactic Body Radiotherapy (SBRT) and Sorafenib in Patients With Metastatic, Recurrent, or Unresectable Renal Cell Cancer (RCC)
NCT00672178 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Evaluate Safety and Tolerability in Dose Escalation of Sorafenib in Advanced Renal Cell Cancer
NCT01189370 ·Status: COMPLETED ·Phase: PHASE2
-
Sunitinib Before and After Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed By Surgery
NCT00747305 ·Status: TERMINATED ·Phase: PHASE1
-
Sorafenib in Treating Patients With Advanced or Metastatic Cancer of the Urinary Tract
NCT00112671 ·Status: COMPLETED ·Phase: PHASE2
-
Sunitinib Before and After Surgery in Treating Patients With Stage IV Kidney Cancer
NCT00717587 ·Status: UNKNOWN ·Phase: PHASE2
-
Sunitinib in Treating Patients With Locally Recurrent or Metastatic Kidney Cancer
NCT00459875 ·Status: COMPLETED ·Phase: PHASE2
-
Sorafenib, Gemcitabine, and Capecitabine in Treating Patients With Unresectable and/or Metastatic Kidney Cancer
NCT00121251 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Sorafenib and RAD001 Renal Cell Carcinoma
NCT00384969 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment of Advanced Renal Cell Carcinoma With Quinacrine
NCT00574483 ·Status: WITHDRAWN ·Phase: PHASE2
-
Dosing and Effectiveness Study of Sorafenib and RAD001 in the Treatment of Patients With Advanced Kidney Cancer
NCT00392821 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Assess Sorafenib Alone and in Combination With Low-Dose Interferon Following Unsuccessful Treatment With Sunitinib in Patients With Advanced Renal Cell Cancer.
NCT00678288 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Sorafenib in Patients With Advanced Renal Cell Carcinoma
NCT00848640 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Recombinant Interleukin 21 in Combination With Sorafenib for Metastatic Renal Cell Carcinoma
NCT00389285 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell Carcinoma
NCT01223027 ·Status: COMPLETED ·Phase: PHASE3