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Molecular Analysis of Retinoblastoma

NCT00718783 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 41

Last updated 2016-12-14

No results posted yet for this study

Summary

Retinoblastoma is a childhood tumor of the retina that affects approximately 1 in 18,000 children. Retinoblastoma is more prevalent in Central America, where most patients present with advanced intraocular and extraocular disease. Therefore, we have formed collaboration with Central American investigators to provide us with frozen retinoblastoma tumors from patients undergoing routine enucleation. The objective of this protocol is to begin to identify the mutations and gene expression changes that occur in retinoblastoma cells following RB1 gene inactivation in order to more effectively target chemotherapy for treating bilateral retinoblastoma.

Conditions

  • Retinoblastoma

Interventions

OTHER

Tissue samples taken from retinoblastoma

Tissue banking

OTHER

5 ml peripheral blood

White blood cells will be isolated from the blood sample as a source of genomic DNA.

Sponsors & Collaborators

Principal Investigators

  • Rachel Brennan, MD · St. Jude Children's Research Hospital

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-04-30
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • Chile
  • Honduras

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00718783 on ClinicalTrials.gov