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Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans

NCT00709839 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2011-06-01

No results posted yet for this study

Summary

The purpose of this study is to investigate the effect of hydrocortisone on glucose-induced insulin secretion and sensitivity, by means of an intravenous glucose tolerance test with frequent sampling (FSIGT) followed by minimal model analysis. In a randomized single-blind cross-over design, the subjects will receive either hydrocortisone or placebo 4 minutes before an intravenous glucose load.

Conditions

  • Healthy

Interventions

DRUG

Hydrocortisone

0.6 mg/kg body weight, intravenous bolus given at time-point minus 4'

DRUG

Glucose 33%

1ml/kg body weight, intravenous bolus given at time-point 0'

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Anton Luger, MD · Medical University of Vienna

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-06-30
Primary Completion
2008-10-31
Completion
2008-12-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00709839 on ClinicalTrials.gov