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MRI to Measure Treatment With Antibiotics in Alzheimer's Disease

NCT00692588 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 58

Last updated 2011-04-06

No results posted yet for this study

Summary

Objectives:

To study the changes in brain structure and function using MRI scans in patients treated for Alzheimer's disease.

Methods:

A pilot study of treating Alzheimer's disease with antibiotics showed some promise that this treatment could delay the deterioration of the mind with this disease. This study is being replicated on a larger scale, providing a more definitive answer to this question. In addition to looking at changes of the mind (through cognitive tests), we would like to use MRI scans in these patients before and after treatment to study the structural changes and the chemical changes in the brain. This would provide a non-invasive look at the bran processes that protect the brain from the effect of Alzheimer's as well as confirming that the disease has been modified with treatment.

Impact:

The novel treatment of Alzheimer's with antibiotics has provided a potential breakthrough in the field. In addition to verifying changes in the brain, MRI scans can observe HOW this process could occur, thus opening doors to other new treatments for Alzheimer's and perhaps even cures.

Conditions

Sponsors & Collaborators

  • St. Peter's Hospital

    collaborator UNKNOWN

  • St. Peter's Centre for Studies in Aging

    collaborator UNKNOWN

  • St. Joseph's Healthcare Hamilton

    lead OTHER

Principal Investigators

  • Mohammed A Warsi, (Hon)BSc, MSc, MD, FRCP(C) · McMaster University

  • Michael D Noseworthy, (Hon)BSc, MSc, PhD · St. Joseph's Hospital

  • William Molloy, MBBch, MRCP, FRCP(C) · St. Peters Hospital

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-06-30
Primary Completion
2010-06-30
Completion
2010-06-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00692588 on ClinicalTrials.gov