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Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter

NCT00686231 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2020-03-06

Study results available
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Summary

The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply. In order to facilitate successful catheterization of the artery, a dilated artery and one free of arterial spasm is desirable. The proposed study will randomize twenty three healthy subjects in 2 visits to determine the effect of topical nitroglycerin on radial artery vasodilation. Radial artery diameter will be measured with ultrasound at regular intervals up to two hours.

Conditions

  • Healthy

Interventions

DRUG

Nitroglycerin 15mg

15mg Nitroglycerin applied topically to one wrist

DRUG

Nitroglycerin 30mg

30mg Nitroglycerin applied topically to one wrist

DRUG

Lidocaine 20mg

20mg Lidocaine applied topically to one wrist in combination with nitroglycerin or placebo

DRUG

Lidocaine 40mg

40mg Lidocaine applied topically to one wrist in combination with nitroglycerin or placebo

DRUG

Placebo

Topical skin moisturizing cream with same appearance as active agent

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00686231 on ClinicalTrials.gov