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The Women's Health Initiative Memory Study (The WHIMS Study)

NCT00685009 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7525

Last updated 2015-10-19

No results posted yet for this study

Summary

Excessive memory decline or dementia affects an increasing number of women as they become older. The frequency of dementia doubles every 5 years beginning at age 60, making the discovery of ways to prevent or slow the disease imperative. Previous studies have indicated that changes in memory may be associated with the female hormonal decline that occurs after menopause, but more research is needed to establish the link between menopause and poorer memory function. It is believed that taking the female hormones estrogen and/or progesterone may help improve women's health by protecting against memory decline. This study will evaluate the effects of female hormone replacement therapy (HRT) on the development and progression of memory loss in older women enrolled in the Women's Health Initiative (WHI) study.

Conditions

  • Dementia Syndromes

Interventions

DRUG

Estrogen hormone therapy

Estrogen pill daily

DRUG

Estrogen plus progesterone hormone therapy

Estrogen plus progesterone hormone therapy pill (Prempro) daily

DRUG

Placebo

Placebo pill daily

Sponsors & Collaborators

  • Wake Forest University Health Sciences

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Sally A. Shumaker, PhD · Wake Forest University Health Sciences

Eligibility

Min Age
65 Years
Max Age
79 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1996-01-31
Primary Completion
1997-09-30
Completion
2008-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00685009 on ClinicalTrials.gov