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Tryptophan, Serotonin and Kynurenine in Septic Shock

NCT00684736 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2008-08-08

No results posted yet for this study

Summary

Septic shock is a major cause of mortality and morbidity worldwide. Serotonin (5-HT) is released by activated platelets into the circulation, and is mediator of endothelial dysfunction. 5-HT metabolism is known in immune system via specific 5-HT receptor, also in effects on the peripheral nervous system. Kinetic of 5-HT, tryptophan, kynurenine, MAO activity and IDO activity in human septic shock was never investigated.

Conditions

  • Shock, Septic

Sponsors & Collaborators

  • Versailles Hospital

    lead OTHER

Principal Investigators

  • Jean-Pierre Bédos, MD, PhD · Versailles Hospital

  • Odile Spreux-Varoquaux, PhD · Versailles Hospital

  • Matthieu Henry-Lagarrigue, MD · Versailles Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-06-30
Primary Completion
2007-04-30
Completion
2008-04-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00684736 on ClinicalTrials.gov