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A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children

NCT00670891 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2008-05-29

No results posted yet for this study

Summary

Autism is a developmental and behavioral pattern which includes the triad of impairments, 1. social interaction 2. social communication 3. imagination. Inevitable difficulties in the treatment, managing and handle with autistic children are the main problems. Their memories are seemingly in picture or photo records, which are difference from normal population. There are many concepts but no concise in causative factors, including useful treatments, useless and prolong remaining in many studies.

HBOT (Hyperbaric Oxygen Therapy) is a quite modern treatment in Thailand for nitrogen imbalance (decompression sickness syndrome or Caisson disease). How can we apply it to treat the autism? A hypothesis shows evidence that neurons surrounding the permanently damaged epicenter of injury can be reactivated with increased oxygen. Oxygen exists in the blood in two forms, combined with hemoglobin and dissolved in plasma. More oxygen is transported by hemoglobin, but oxygen is delivered to the tissues in dissolved form by the liquid portion of blood. HBOT can increase in plasma oxygen to the tissues including the brain. A little change in oxygen can make the better improvements in : cognitive ability, socialization, sleep, calmness, decreased stimming and language. It can make increased in Glutathione (GSH), and Glutathione (GSH) can decreased in oxidative stress with effected to remove metal compounds (mercury) to improve the autism.

This clinical trial study divided into 3 group populations 1. general autism 2. post-treatment chiropractic autism 3. medicated autism. This comparative study shows the major clinical symptoms before and after the treatment with HBOT. This study results and analysis are the most important for our further projects planning.

Conditions

  • Autistic Disorder

Interventions

PROCEDURE

oxygen (Hyperbaric Oxygen Therapy)

Current Accepted Applications of HBOT (2008) Jan 2003, ANDI International 1. Air or Gas Embolus 2. Decompression Illness 3. Carbon Monoxide poising 4. Clostridial Myonecrosis (Gas Gangrene) 5. Necrotizing Fasciitis 6. Crush Injury (Compartment syndromes) 7. Selected Problem Wounds 8. Compromised Skin Flaps or Grafts 9. Refractory Osteomyelitis 10. Exceptional Anemia due to Blood loss 11. Osteoradionecrosis 12. Thermal Burns and Radiation Tissue Damage 13. Diabetic Wounds 14. Intra-Cranial Abscess 15. Brain Injury and other Head Trauma 16. Cerebral Palsy 17. High Altitude Sickness 18. Lyme disease

Sponsors & Collaborators

  • Vachira Phuket Hospital

    lead OTHER

Principal Investigators

  • Jessada Chungpaibulpatana, MD. · Vachira Phuket Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
5 Years
Max Age
9 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-07-31
Primary Completion
2008-04-30
Completion
2008-04-30

Countries

  • Thailand

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00670891 on ClinicalTrials.gov