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Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure

NCT00670124 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2014-11-05

No results posted yet for this study

Summary

Treatment options in patients with high intracranial pressure due to acute liver failure are limited. This study intends to evaluate the effect of prophylactic hypothermia on preventing high intracranial pressure and compromised cerebral oxidative metabolism.

Conditions

  • Acute Liver Failure
  • Intracranial Hypertension

Interventions

DEVICE

Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero

The patients are placed on a cooling mattress and body-core temperature is regulated to 33° C.

Sponsors & Collaborators

  • University Hospital Birmingham

    collaborator OTHER

  • Northwestern University Feinberg School of Medicine

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Fin S Larsen, MD · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2011-01-31
Completion
2011-06-30

Countries

  • United States
  • Denmark
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00670124 on ClinicalTrials.gov