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Diet, Exercise, Metabolism, and Obesity in Older Women

NCT00664729 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 112

Last updated 2018-08-01

No results posted yet for this study

Summary

Reductions in fat oxidation and resting metabolic rate (RMR) are associated with normal aging and are accelerated with menopause. As a result, postmenopausal women have an increased risk of abdominal obesity and ultimately the metabolic complications that lead to the insulin resistance syndrome and its associated risks (hyperlipidemia, type 2 diabetes, and coronary heart disease). Thus, there is a need to determine the most successful treatment to reduce visceral obesity in postmenopausal women. The purpose of this study is to determine if dietary-induced weight loss alone and/or weight loss combined with exercise at low and high- intensities differentially affect the reduction in visceral adipose tissue in postmenopausal women with abdominal obesity.

Conditions

  • Abdominal Obesity
  • Metabolic Syndrome

Interventions

BEHAVIORAL

Caloric Restriction

Reduced calorie diet (400 kcal/day deficit)

BEHAVIORAL

Caloric Restriction + Low-Intensity aerobic exercise

400 kcal/day deficit plus 3 days/week aerobic exercise at 45-50% maximal aerobic fitness

BEHAVIORAL

Caloric Restriction plus High-intensity aerobic exercise

400 kcal/day deficit and 3 d/week of aerobic exercise at 65-75% maximal fitness

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Wake Forest University Health Sciences

    lead OTHER

Principal Investigators

  • Barbara J Nicklas, PhD · Wake Forest University Health Sciences

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2002-11-30
Primary Completion
2008-11-30
Completion
2008-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00664729 on ClinicalTrials.gov