Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma
NCT00659568 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 28
Last updated 2013-05-30
Summary
RATIONALE: Metformin and temsirolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
PURPOSE: This phase I trial is studying the side effects and best dose of metformin when given together with temsirolimus in treating patients with metastatic or unresectable solid tumor or lymphoma.
Conditions
- Breast Cancer
- Endometrial Cancer
- Kidney Cancer
- Lung Cancer
- Lymphoma
- Unspecified Adult Solid Tumor, Protocol Specific
Interventions
- DRUG
-
metformin hydrochloride
- DRUG
-
temsirolimus
Sponsors & Collaborators
-
London Health Sciences Centre
lead OTHER
Principal Investigators
-
Mary Mackenzie, MD · London Health Sciences Centre
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-03-31
- Primary Completion
- 2010-02-28
- Completion
- 2010-08-31
Countries
- Canada
Study Locations
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