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Impact of Oral Contraceptives on GABA and Neurosteroids

NCT00656318 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2009-08-25

No results posted yet for this study

Summary

Thus, the proposed study has the following Specific Aims and Hypotheses:

1. To determine in menstruating women ages 18-45 whether an OCP containing ethinyl estradiol (EE) and the progestin ethinydiol diacetate (ED) increases cortical GABA concentrations as measured using proton magnetic resonance spectroscopy (1H-MRS) above that of an OCP containing EE and the progestin norethindrone (NOR).
2. To determine the relationship between changes in occipital GABA concentrations with acute OCP administration and negative affect with chronic OCP administration over two menstrual cycles.

Conditions

  • Healthy

Interventions

OTHER

oral contraceptive pill (OCP; OCPs)

Daily administration of oral contraceptive pill for up to 3 months (2 months of daily administration required for the study).

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • C. Neill Epperson, M.D. · Yale University School of Medicine, Department of Psychiatry

Eligibility

Min Age
18 Years
Max Age
42 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-08-31
Primary Completion
2009-03-31
Completion
2009-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00656318 on ClinicalTrials.gov