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Upright Versus Supine Exercise Testing in Fontan-palliated Patients

NCT00633815 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2017-05-10

No results posted yet for this study

Summary

Fontan-palliated patients comprise an interesting group of single-ventricle patients who are dependent upon passive return of blood from the body to the lungs. Systemic venous pressures are therefore quite elevated, and one study demonstrated that venous capacitance was diminished. In addition, these patients have markedly diminished aerobic capacity (Max VO2). Although one recent study demonstrated that Fontan patients can increase their Max VO2 through diligent cardiac rehabilitation, their ultimate results were still well below average.

It has previously been described that normal, healthy subjects have decreased exercise performance in a supine vs upright position. However, due to high venous pressures and the need for systemic venous return to overcome gravity in order to perfuse the lungs, one might hypothesize that Fontan patients would have increased exercise performance in a supine vs upright position. The investigators are interested in studying this hypothesis.

Conditions

  • Fontan Palliation

Interventions

OTHER

Supine positioning

Subjects underwent exercise testing on a stationary bicycle in the supine position

OTHER

Upright positioning

Subjects underwent exercise testing on a stationary bicycle in the upright position

Sponsors & Collaborators

Eligibility

Min Age
8 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2008-11-30
Completion
2008-11-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00633815 on ClinicalTrials.gov