Variations in the Hemostatic System Induced by a Standardized Walking Test

Summary

Two groups of patients will be compared: One group of patients with a history of venous thromboembolic disease and one group without. Both groups will be subjected to a walking test and with electrocardiogram measurements and blood tests.

Conditions

• Venous Thromboembolism

Interventions

OTHER

60-minute walking test

Treadmill walking test in the morning, 2 hours after breakfast, following a clinical examination, resting 12-lead electrocardiogram and blood pressure measurement. After a 3-minute warm-up and walking of speed 2.5 km per hour, no incline, the speed and incline are gradually increased to reach a target heart rate close to the theoretical ventilatory threshold, around 70% of the theoretical maximum value (evaluated by Astrand's formula: 220-age), i.e. aerobic conditions of moderate intensity so that prolonged effort can be maintained. Test performed in presence of a physician trained in stress testing. Emergency cart and defibrillator available in the department. Intra-hospital vital emergency protocol in place, with resuscitation teams on standby. The cardiology department, in the same building, can be contacted in the event of a cardiological abnormality during the test or recovery. The test takes 60 minutes, including a 3-minute initial warm-up.

DIAGNOSTIC_TEST

Static blood test

33.3 ml of blood will be taken from each participant whilst at rest, before undergoing the 60-minute walking test

DIAGNOSTIC_TEST

Post-effort blood test

33.3 ml of blood will be taken from each participant immediately after undergoing the 60-minute walking test.

OTHER

Electrocardiogram

An electrocardiogram will be carried out throughout the exercise period and during the first 30 minutes of recovery.

OTHER

Blood pressure monitoring

Blood pressure will be monitored out throughout the exercise period and during the first 30 minutes of recovery.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes

  lead OTHER

Principal Investigators

• Antonia PEREZ MARTIN, Prof. · Nîmes University Hospital

• Stéphane FAURE · Nîmes University Hospital

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-02-11

Primary Completion

2027-04-01

Completion

2027-04-01

Countries

• France

Study Locations