Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours
NCT00621725 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2014-07-15
Summary
To determine how patients with advanced cancer and various degrees of hepatic impairment will metabolise Cediranib.
Conditions
- Advanced Cancer
- Hepatic Impairment
Interventions
- DRUG
-
AZD2171
Oral dose
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
CML van Herpen, MD · Radboud University Medical Center
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-01-31
- Primary Completion
- 2010-07-31
- Completion
- 2014-01-31
Countries
- Denmark
- Netherlands
Study Locations
More Related Trials
-
Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies
NCT01364051 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase I Study With AZD2171 in Patients With Advanced Solid Malignant Tumors and Liver Metastases
NCT00501605 ·Status: COMPLETED ·Phase: PHASE1
-
Absorption, Metabolism, Excretion and Pharmacokinetics of a Single Dose [14C]AZD2014 Followed by a Multiple Dose Phase
NCT02640755 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess Safety, Tolerability and PK of AZD2171 and Chemotherapy on Patients With Solid Tumors
NCT00502567 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Comparative Bioavailability Study
NCT00777582 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase I Orally Administered 14C-AZD2171 in Patients With Solid Metastatic Tumors
NCT00503412 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours
NCT04999969 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours
NCT02617277 ·Status: COMPLETED ·Phase: PHASE1
-
Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.
NCT02610075 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours
NCT02482311 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of AZD2014
NCT01026402 ·Status: COMPLETED ·Phase: PHASE1
-
AZD1775 Continued Access Study to Assess Safety and Tolerability for Patients Enrolled in AZD1775 Clinical Pharmacology Studies
NCT03313557 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Study to Assess the Effect of Food on AZD1775 Pharmacokinetics in Patients With Advanced Solid Tumours
NCT03315091 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I AZD2281/Cisplatin in Advanced Solid Tumour Patients
NCT00782574 ·Status: COMPLETED ·Phase: PHASE1
-
AZD1775 Combined With Olaparib in Patients With Refractory Solid Tumors
NCT02511795 ·Status: COMPLETED ·Phase: PHASE1
-
An Open-Label Pharmacokinetics and Safety Study of Talazoparib
NCT02997163 ·Status: COMPLETED ·Phase: PHASE1
-
AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies
NCT00463814 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Phase I Study of Safety, Tolerability, and PK of AZD2811 in Patients With Advanced Solid Tumors.
NCT02579226 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD6918
NCT00733031 ·Status: TERMINATED ·Phase: PHASE1
-
AZD2171 + Chemotherapy in Advanced NSCLC, Colorectal Cancer, or Other Cancer Suitable for Treatment With Capecitabine (Non-Small Lung Cancer Patients Closed to Enrollment as 8/9/07)
NCT00107250 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I-II Study With Tumor Molecular Pharmacodynamic (MPD) Evaluation and Pharmacokinetics of PD-0332991 in Patients Suffering Metastatic Melanoma
NCT02202200 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment
NCT01894243 ·Status: COMPLETED ·Phase: PHASE1
-
Study for AZD4360 in Participants With Advanced Solid Tumours
NCT06921928 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
An Open-Label Pharmacokinetics and Safety Study of Talazoparib (MDV3800)
NCT02997176 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors
NCT02498613 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2