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Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance

NCT00615225 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2008-02-14

No results posted yet for this study

Summary

We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction. In this study of brain-dead donors and controls, we assayed plasma cytokines and soluble factors, investigated plasma endotoxin levels as a triggering factor for inflammation, measured ex vivo cytokine production by blood leukocytes to determine whether immunosuppression occurred after brain death, and examined skeletal muscle biopsies to look for evidence of inflammation and increased apoptosis in peripheral tissue.

Conditions

  • Brain Death

Interventions

PROCEDURE

Muscle biopsy

Muscle biopsies were taken through the operation site from the vastus lateralis thigh muscle at the beginning of surgery

Sponsors & Collaborators

  • Delafontaine Hospital

    lead OTHER

Principal Investigators

  • Christophe Adrie, MD, PhD · Delafontaine Hospital

  • Jean Marc Cavaillon, ScD · Pasteur Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2000-01-31
Primary Completion
2007-11-30
Completion
2007-12-31

Countries

  • Belgium
  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00615225 on ClinicalTrials.gov