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The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries

NCT00612469 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 69

Last updated 2008-02-11

No results posted yet for this study

Summary

The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or 10% vancomycin, during 6 consecutive days. This clinical trial was designed to test two different hypotheses. First, that topical vancomycin would be more effective than chlorhexidine and sodium fluoride in salivary MS reduction. Secondly, a 6-day antimicrobial treatment with either one of these agents would produce a long lasting MS suppression, dispensing repeated antibacterial treatments.

Conditions

  • Dental Caries

Interventions

DRUG

Sodium Fluoride

Topical application of 1.23% sodium fluoride to the dentition, every 24 hours, during 6 consecutive days

DRUG

vancomycin hydrochloride

Topical application of 3% vancomycin hydrochloride to the dentition, every 24 hours, during 6 consecutive days

DRUG

vancomycin hydrochloride

Topical application of 10% vancomycin hydrochloride to the primary dentition, every 24 hours, during 6 consecutive days

DRUG

chlorhexidine digluconate

Topical application of 1% chlorhexidine digluconate to the dentition, every 24 hours, during 6 consecutive days

Sponsors & Collaborators

  • Universidade Federal do Ceara

    lead OTHER

Principal Investigators

  • Cristiane SR Fonteles, DDS, MS, PhD · Federal University of Ceará

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
4 Years
Max Age
8 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-10-31
Primary Completion
2006-07-31
Completion
2006-10-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00612469 on ClinicalTrials.gov