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Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients

NCT00610324 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 512

Last updated 2008-02-07

No results posted yet for this study

Summary

Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open heart surgery. Its role in critically ill general ICU patients is not yet proven. The present study proposes to study the effectiveness of twice-daily oral cleansing with 0.2% chlorhexidine solution on the incidence of nosocomial pneumonia in ICU patients admitted to a single intensive care unit of an Indian public hospital

Conditions

  • Nosocomial Pneumonia
  • Healthcare-Associated Pneumonia
  • Aspiration Pneumonia
  • Ventilator-Associated Pneumonia

Interventions

DRUG

Chlorhexidine gluconate

Twice-daily oropharyngeal cleansing with 0.2% Chlorhexidine gluconate

DRUG

Potassium permanganate

Twice-daily oropharyngeal cleansing with 0.01% Potassium permanganate

Sponsors & Collaborators

  • King Edward Memorial Hospital

    lead OTHER

Principal Investigators

  • Dilip R Karnad, MD,FACP,FRCP · Professor of Medicine, K E M Hospital, Parel, Mumbai 400012, India

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
13 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-05-31
Primary Completion
2007-10-31
Completion
2007-12-31

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00610324 on ClinicalTrials.gov