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Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

NCT00603720 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2018-09-12

Study results available
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Summary

The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.

Conditions

Interventions

DRUG

L-NAME

nitric oxide synthase inhibitor 4mg/kg infusion over 30-60 minutes prior to PET imaging

DRUG

L-Arginine

aids in nitric oxide production

DRUG

Phenylephrine

alpha agonist; 10 μg/kg/min infusion during PET study

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Robert Gropler, MD · Washington University School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-09-30
Primary Completion
2008-06-30
Completion
2008-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00603720 on ClinicalTrials.gov