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Proton Radiotherapy With Chemotherapy for Nasopharyngeal Carcinoma

NCT00592501 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2021-10-26

Study results available
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Summary

Photon beam radiation is the standard type of radiation used to treat nasopharyngeal carcinoma. Photon beam radiation enters the body and passes through healthy tissue, encounters the tumor and leaves the body through healthy tissue. Proton beam radiation has been shown to have the same effect on tumors as photon beam radiation but it enters the body, passes through healthy tissue, and encounters the tumor but then stops. This means less healthy tissue is affected by proton beam treatment than by photon beam treatment. The purpose of this study is to determine the effectiveness of proton beam radiation in treating nasopharyngeal cancer and reducing the acute and long-term side effects from the treatment. This study will also test to see if the sparing of the healthy tissue can improve quality of life

Conditions

  • Nasopharyngeal Carcinoma

Interventions

RADIATION

Proton/Photon Radiotherapy

Given once a day, five days a week, for seven weeks.

DRUG

Cisplatin

Given intravenously once every three weeks during radiation treatment, then once every four weeks for three cycles.

DRUG

Fluorouracil

Given as continuous infusion over 4 days starting on the day cisplatin is received after radiation therapy.

Sponsors & Collaborators

Principal Investigators

  • Annie W Chan, MD · Massachusetts General Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-10-31
Primary Completion
2019-04-30
Completion
2019-04-30

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00592501 on ClinicalTrials.gov