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Brain Imaging Studies of the Effects of Cocaine Abstinence

NCT00581282 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2021-01-25

No results posted yet for this study

Summary

This study evaluates theories regarding cocaine abstinence which propose that increased presynaptic and postsynaptic dopamine activity and increased serotonin activity are associated with abstinence in cocaine dependent subjects at the beginning and three to six months after a treatment program. We are using positron emission tomography (PET), Magnetic Resonance Imaging (MRI) and diffusion tensor imaging (DTI) in cortical and subcortical areas in a series of brain imaging studies testing these theories of abnormalities in the dopamine and serotonin system for cocaine addiction by examining the distribution of 18F-fallypride, 18F-altanserin, and FDG. We are evaluating genetic theories associated with cocaine addiction through the examination of genetic markers and functional genomics.

Conditions

  • Substance Abuse Disorder

Interventions

RADIATION

PET scan

positron emission tomography PET scan

OTHER

fMRI

functional magnetic resonance imaging fMRI

Sponsors & Collaborators

Principal Investigators

  • Joseph C Wu, M.D. · University of California, Irvine

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-12-31
Primary Completion
2005-12-31
Completion
2005-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00581282 on ClinicalTrials.gov