Isoprostane/FMD Study The Effect of Protein Kinase C (PKC) β Specific Inhibitor LY333531 on Oxidant Stress in Patients With Type 2 Diabetes Mellitus
NCT00552227 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2016-07-26
Summary
The purpose of this study is to determine whether ruboxistaurin can reduce blood vessel inflammation associated with diabetes.
Conditions
Interventions
- DRUG
-
ruboxistaurin
oral 32 mg daily
- OTHER
-
placebo
placebo
Sponsors & Collaborators
-
Chromaderm, Inc.
lead INDUSTRY
Principal Investigators
-
Muredach Reilly, MD · University of Pennsylvania, Philadelphia
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 35 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2002-09-30
- Completion
- 2005-07-31
Countries
- United States
Study Locations
More Related Trials
-
Pharmacokinetic Profile of Two Formulations of PB1023 Following Single Subcutaneous Injection in Subjects With Type 2 Diabetes Mellitus
NCT01427257 ·Status: COMPLETED ·Phase: PHASE1
-
The Effect of Rosiglitazone on Ischemia-reperfusion-injury Using Annexin A5 Scintigraphy.
NCT00405015 ·Status: COMPLETED ·Phase: PHASE2
-
Role of Rosiglitazone on Pre-Diabetes Mellitus and Coronary Artery Disease
NCT01574820 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase 2 Study of Cyclo-Z in Subjects With Type 2 Diabetes
NCT03560271 ·Status: COMPLETED ·Phase: PHASE2
-
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of KRP-104 in Patients With Type 2 Diabetes Inadequately Controlled on Metformin Alone
NCT00525330 ·Status: COMPLETED ·Phase: PHASE2
-
Effects of Pioglitazone on Platelet Function
NCT00861341 ·Status: COMPLETED ·Phase: PHASE2
-
Pharmacodynamic Study of the Effect of INCB013739 on Insulin Sensitivity in Obese, Type 2 Diabetic Subjects
NCT00478322 ·Status: COMPLETED ·Phase: PHASE2
-
Rosiglitazone to Reverse Metabolic Defects in Diabetes
NCT00094796 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Pharmacokinetics Study of XOMA 052 in Subjects With Type 2 Diabetes Mellitus
NCT00513214 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Effect of Rosiglitazone on the Vascular Biology of Human Fat Tissue
NCT01150981 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 2 Study of DS-8500a in Patients With Type 2 Diabetes
NCT02222350 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Investigate in Healthy Volunteers (Part 1) and in Patients With Type 2 Diabetes Mellitus (Part 2) the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of RO6799477
NCT02164266 ·Status: COMPLETED ·Phase: PHASE1
-
Pioglitazone and Serum Asymmetric Dimethylarginine (ADMA) in Patients With Diabetes
NCT00770367 ·Status: COMPLETED ·Phase: PHASE4
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS in Patients With Type 2 Diabetes
NCT02183350 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 135585 XX in Patients With Type 2 Diabetes
NCT01282970 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
NCT05158244 ·Status: COMPLETED ·Phase: PHASE1
-
Effects of ISIS 113715 on Insulin Sensitivity, Glucose, and Lipid Metabolism and Energy Expenditure in Type 2 Diabetics
NCT00330200 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Ro 205-2349 in Patients With Type 2 Diabetes Mellitus
NCT00057317 ·Status: COMPLETED ·Phase: PHASE2
-
Rosiglitazone In Subjects With Type 2 Diabetes Mellitus Who Are Inadequately Controlled On Insulin
NCT00329225 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Pioglitazone on Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus
NCT00232362 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study to Evaluate Safety, Efficacy of PBI-4050 & Its Effect on Relevant Biomarkers in T2DM Patients With Metabolic Syndrome
NCT03081598 ·Status: TERMINATED ·Phase: PHASE2
-
Effect Of Rosiglitazone On Carotid Intima Media Thickness In Patients With Insulin Resistance Syndrome And/Or Type 2 Diabetes
NCT00306644 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Treatment With Balaglitazone in Type 2 Diabetes Patients on Stable Insulin Therapy
NCT00515632 ·Status: COMPLETED ·Phase: PHASE3
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8655 in Participants With Type 2 Diabetes (MK-8655-002)
NCT01640873 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)
NCT01407003 ·Status: COMPLETED ·Phase: PHASE1/PHASE2