Study of XL228 Administered Intravenously to Subjects With Advanced Malignancies
NCT00526838 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 84
Last updated 2015-08-21
Summary
The purpose of this study is to assess the safety and tolerability of the multi-targeted protein kinase inhibitor XL228 (active against IGF1R, Src, FGFR, and BCR-Abl) administered as a once- or twice-weekly 1-hour intravenous infusion in subjects with advanced malignancies.
Conditions
Interventions
- DRUG
-
XL228
1-hour IV infusion
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2007-09-30
- Primary Completion
- 2010-12-31
- Completion
- 2010-12-31
Countries
- United States
Study Locations
More Related Trials
-
Safety Study of AMG 228 to Treat Solid Tumors
NCT02437916 ·Status: TERMINATED ·Phase: PHASE1
-
Dose Escalation Study With MK-2206 in Patients With Locally Advanced or Metastatic Solid Tumors (MK-2206-002)
NCT00670488 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I, Study to Evaluate the Safety and Tolerability of Intravenous EZN-2208 in Patients With Advanced Solid Tumors or Lymphoma (EZN-2208-01)
NCT00520637 ·Status: COMPLETED ·Phase: PHASE1
-
MSX-122 Administered Orally in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
NCT00591682 ·Status: SUSPENDED ·Phase: PHASE1
-
Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma
NCT01177397 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
NCT03517488 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study Of An Intravenously Administered Cyclin-Dependent Kinase Inhibitor In Patients With Advanced Cancer
NCT00147485 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 1 Study of AMG 208 in Subjects With Advanced Solid Tumors
NCT00813384 ·Status: COMPLETED ·Phase: PHASE1
-
Study of XL281 in Adults With Solid Tumors
NCT00451880 ·Status: COMPLETED ·Phase: PHASE1
-
Study of XL820 in Adults With Solid Tumors
NCT00129571 ·Status: COMPLETED ·Phase: PHASE1
-
Study of XL820 Given Orally Daily to Subjects With Solid Tumors
NCT00350831 ·Status: COMPLETED ·Phase: PHASE1
-
Safety Study of Pharmacokinetics of XL888 in Adults With Solid Tumors
NCT00796484 ·Status: TERMINATED ·Phase: PHASE1
-
Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects
NCT01359982 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study of PLX038 in Patients With Advanced Solid Tumors
NCT02646852 ·Status: COMPLETED ·Phase: PHASE1
-
An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies
NCT02431260 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study to Assess Safety, Tolerability and PK of AZD1480 in Patients With Solid Tumours
NCT01112397 ·Status: TERMINATED ·Phase: PHASE1
-
Study of SGI-1776, a PIM Kinase Inhibitor, in Subjects With Relapsed/Refractory Leukemias
NCT01239108 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study of PF-05212384 (Also Known as PKI-587)Administered Intravenously To Subjects With Solid Tumors
NCT00940498 ·Status: COMPLETED ·Phase: PHASE1
-
PF-07284892 in Participants With Advanced Solid Tumors
NCT04800822 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I, Study to Evaluate the Safety and Tolerability of Intravenous EZN-2208 in Patients With Advanced Solid Tumors or Lymphoma (EZN-2208-02)
NCT00520390 ·Status: COMPLETED ·Phase: PHASE1
-
A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies
NCT01004224 ·Status: COMPLETED ·Phase: PHASE1
-
XTX202 in Patients With Advanced Solid Tumors
NCT05052268 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma
NCT01421524 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study Evaluating CB-5083 in Subjects With Advanced Solid Tumors
NCT02243917 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of BTX-1188 in Subjects With Advanced Malignancies
NCT05144334 ·Status: TERMINATED ·Phase: PHASE1