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Effect of Folic Acid on Endothelial and Baroreceptor Function in Patients With Heart Failure

NCT00491907 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2007-10-02

No results posted yet for this study

Summary

The randomized, double-blind, placebo-controlled study aim to evaluate the effect of 1-month therapy with folic acid (5 mg/day) on endothelial function and baroreceptor function in patients with heart failure.

Endothelial function will be studied non-invasively with flow-mediated dilation while for eveluating baroreceptor function sympathetic nervous system activity will be measured directly with microneurography in baseline condition and during infusion of sodium-nitroprusside.

Conditions

Interventions

DRUG

folic acid 5mg/day

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Georg Noll, MD · Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-10-31
Completion
2007-05-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00491907 on ClinicalTrials.gov