Evaluation of 123-I Iodobenzovesamicol (IBVM) and SPECT Imaging of Healthy Subjects and Patients With Alzheimer Disease
NCT00480701 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 26
Last updated 2014-05-07
Summary
The underlying goal of this study is to assess 123-I IBVM SPECT imaging as a tool to assess cholinergic transporter binding in the brain of AD and PD research participants and age- and gender-matched healthy subjects.
Conditions
- Alzheimer Disease
- Parkinson Disease
Interventions
- DRUG
-
[123I]-IBVM
Subjects will be asked to undergo an injection of 123-I IBVM followed by up to three approximately thirty minute SPECT scans during the next 24 hours.
Sponsors & Collaborators
-
Institute for Neurodegenerative Disorders
lead OTHER
Principal Investigators
-
Danna Jennings, MD · Institute for Neurodegenerative Disorders
Study Design
- Allocation
- NA
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2007-02-28
- Primary Completion
- 2011-10-31
- Completion
- 2011-10-31
Countries
- United States
Study Locations
More Related Trials
-
Bisnorcymserine in Healthy Adult Volunteers
NCT01747213 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [123I] MNI-308 and SPECT as a Marker of Beta-amyloid Protein Deposition in AD Subjects Compared to HC
NCT00544453 ·Status: TERMINATED ·Phase: PHASE1
-
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
NCT04430517 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
MW151-101: First-in-human Study of MW151
NCT04120233 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [123I] AV51 and SPECT as a Marker of Beta-amyloid Protein Deposition in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
NCT00556660 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [123I] MNI-340 and SPECT as a Marker of Beta-Amyloid Protein Deposition
NCT00968097 ·Status: TERMINATED ·Phase: PHASE1
-
Positron Emission Tomography (PET) Amyloid Imaging of the Brain in Healthy Young Adult Subjects
NCT01265394 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of SHR-1707 in Healthy Young Adult and Elderly Subjects
NCT04973189 ·Status: COMPLETED ·Phase: PHASE1
-
A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD)
NCT05551741 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Pharmacodynamics of SHR-1707 in Alzheimer's Disease Patients
NCT06199037 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of SHR-1707 With Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease
NCT05681819 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease
NCT01492374 ·Status: COMPLETED ·Phase: PHASE1
-
Ability Of ([18F]-AV-45) PET Scan to Distinguish Alzheimer's Disease Subjects From Cognitively Normal Individuals
NCT00855868 ·Status: COMPLETED ·Phase: PHASE2
-
Neurostimulation for Cognitive Enhancement in Alzheimer's Disease
NCT04404153 ·Status: COMPLETED ·Phase: NA
-
Positron Emission Tomography Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects
NCT00686413 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of CT1812 Treatment on Brain Synaptic Density
NCT03493282 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Electrophysiologic Measures of Treatment Response in Alzheimer Disease
NCT00018278 ·Status: COMPLETED ·Phase: PHASE4
-
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies
NCT03467152 ·Status: COMPLETED ·Phase: PHASE2
-
A Preliminary Study of 18F-AV-45 in Alzheimer's Disease and Healthy Elderly Volunteers
NCT01565291 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI)
NCT01565382 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Determine the Biodistribution, Safety, and Tolerability of a Microdose of Radiolabeled BIIB080 Co-administered With BIIB080 in Healthy Adults
NCT06454721 ·Status: COMPLETED ·Phase: PHASE1
-
A Randomized, Double-blind, Placebo-controlled Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamic Response of Repeated Intravenous Infusions of BAN2401 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease
NCT02094729 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease
NCT02353598 ·Status: COMPLETED ·Phase: PHASE1
-
Initial Investigation of [18F]P16-129 in Alzheimer's Disease Patients and Healthy Volunteers
NCT03902548 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment
NCT02573740 ·Status: TERMINATED ·Phase: PHASE1