Developing Objective Measures of Levodopa Induced Dyskinesia: (Study 1)
NCT00467597 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36
Last updated 2014-11-26
Summary
The ultimate goal of this proposal is to reduce dyskinesia in Parkinson's Disease (PD) patients. Dyskinesias are abnormal movements, often caused by the standard treatment for PD symptoms, levodopa. In this study, we will test if biochemical devices are equal to the clinical rating system in measuring dyskinesias.
Conditions
- Dyskinesias
- Movement Disorders
- Parkinson Disease
Interventions
- DRUG
-
Levodopa (delivered intravenously)
IV Levodopa is given from 09:00 to 11:00 am during the testing phase of the study. The IV Levodopa allows the researchers to watch one full "on" and "off" levodopa cycle while in the inpatient unit.
Sponsors & Collaborators
-
Oregon Health and Science University
collaborator OTHER -
US Department of Veterans Affairs
lead FED
Principal Investigators
-
Kathryn Anne Chung, MD · VA Medical Center, Portland
Eligibility
- Min Age
- 21 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2006-04-30
- Primary Completion
- 2008-08-31
- Completion
- 2013-10-31
Countries
- United States
Study Locations
More Related Trials
-
Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease
NCT00666653 ·Status: COMPLETED ·Phase: PHASE1
-
Levodopa Response and Gut Microbiome in Patients With Parkinson's Disease
NCT04956939 ·Status: COMPLETED
-
Phase I Open-label Study of Low-dose Ketamine Infusion Treatment in Levodopa-Induced Dyskinesia in Parkinson's Disease
NCT06021756 ·Status: UNKNOWN ·Phase: PHASE1
-
Intravenous Levodopa for the Diagnosis of Parkinson's Disease
NCT00001928 ·Status: COMPLETED
-
Study Comparing Intravenous and Subcutaneous Infudopa With Intestinal Duodopa in Patients With Parkinson's Disease
NCT03419806 ·Status: COMPLETED ·Phase: PHASE1
-
Dyskinesia in Parkinson's Disease (Study P04501)
NCT00406029 ·Status: COMPLETED ·Phase: PHASE2
-
High and Low Dose Carbidopa Treatment of Parkinson's Disease
NCT01399905 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
NCT00357994 ·Status: COMPLETED ·Phase: PHASE3
-
Vigor and the LDR in Parkinson Disease
NCT04821830 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease
NCT05487300 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia
NCT01092065 ·Status: COMPLETED ·Phase: PHASE2
-
EMD 128130 for the Treatment of Parkinson's Disease
NCT00009048 ·Status: COMPLETED ·Phase: PHASE2
-
Study of LY300164 for the Treatment of Parkinson's Disease
NCT00004576 ·Status: COMPLETED ·Phase: PHASE2
-
Sustained Release Oral Formulation for Treatment of Parkinson's Disease
NCT05471609 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Pharmacokinetic of Levodopa Study in Healthy Males
NCT03140956 ·Status: COMPLETED ·Phase: PHASE1
-
Acute Effects of Preladenant (SCH 420814) on Dyskinesia and Parkinsonism in Levodopa Treated Participants (P05550)
NCT00845000 ·Status: COMPLETED ·Phase: PHASE1
-
Carbidopa/Levodopa/Entacapone Versus Immediate Release (IR) Carbidopa/Levodopa on Non-motor Symptoms in Patients With Idiopathic Parkinson's Disease and Demonstrating Non-motor Symptoms of Wearing Off
NCT00642356 ·Status: TERMINATED ·Phase: PHASE4
-
Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
NCT00099268 ·Status: COMPLETED ·Phase: PHASE3
-
A Single Period Investigation to Assess the Tolerability of Healthy Subjects to Oral Sinemet® (Levodopa/Carbidopa)
NCT02486432 ·Status: COMPLETED ·Phase: PHASE1
-
JP-1730 to Treat Parkinson's Disease
NCT00040209 ·Status: COMPLETED ·Phase: PHASE2
-
Study of NP002 in Subjects With Idiopathic Parkinson's Disease to Treat Dyskinesias Due to Levodopa Therapy
NCT00957918 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Levetiracetam Treatment in Adult Subjects With Parkinson's Disease Experiencing Troublesome Dyskinesias
NCT00160576 ·Status: COMPLETED ·Phase: PHASE2
-
A Pharmacodynamics and Safety Study of DSP-9632P in Patients With Levodopa-Induced Dyskinesia in Parkinson's Disease
NCT05435729 ·Status: COMPLETED ·Phase: PHASE1
-
A Clinical Study of Efficacy, Safety, Tolerability and PK of ND0612H in Subjects With Advanced Parkinson's Disease
NCT02577523 ·Status: COMPLETED ·Phase: PHASE2
-
Buspirone, in Combination With Amantadine, for the Treatment of Levodopa-induced Dyskinesia
NCT02589340 ·Status: TERMINATED ·Phase: PHASE1