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Functional MRI of Cognitive Control in Autism

NCT00463164 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2007-04-20

No results posted yet for this study

Summary

This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.

Conditions

Sponsors & Collaborators

  • UMC Utrecht

    lead OTHER

Principal Investigators

  • Sarah Durston, Ph.D. · Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht

  • Herman van Engeland, M.D. Ph.D. · Rudolf Magnust Institute of Neuroscience, UMC Utrecht

Eligibility

Min Age
6 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-12-31

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00463164 on ClinicalTrials.gov