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The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis

NCT00459511 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2007-04-12

No results posted yet for this study

Summary

Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome.

Adrenomedullin is elevated in SIRS, sepsis and septic shock and has been demonstrated the inhibitory role on insulin and adrenocorticotropic hormone secretion.

Our hypothesis is that: AM elevation after SIRS could be the responsible to maintain hyperglycemia

Conditions

Interventions

PROCEDURE

Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin

Sponsors & Collaborators

  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.

    collaborator OTHER_GOV

  • University of Sao Paulo

    lead OTHER

Principal Investigators

  • Thelma Okay, PHD · Childrens Institute / Molecular Biology

Eligibility

Min Age
2 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-01-31
Completion
2006-10-31

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00459511 on ClinicalTrials.gov