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Weight Loss in Obese Children and Adolescents and Its Effect on Improvement of Destructive Changes in Blood Vessels

NCT00439933 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2007-05-09

No results posted yet for this study

Summary

Obesity in children and adolescents is associated with morphologic and functional changes of the vascular wall, suggesting a potential role of juvenile obesity for the development of atherosclerosis later in life. However, no evidence from intervention studies has been provided so far that weight loss in obese children can improve vascular function. Therefore we designed this study including a cohort of obese children before and after a structured weight reduction program in order to answer the question, whether such an intervention can improve vascular function and reverse destructive vascular changes.

Conditions

Interventions

BEHAVIORAL

low fat and polysaccharide rich diet

BEHAVIORAL

specific physical training program for obese children

Sponsors & Collaborators

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Joerg Tafel, Dr · University Hospital Heidelberg, Department of Internal Medicine I

  • Peter P Nawroth, Prof · University Hospital Heidelberg, Department of Internal Medicine I

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
7 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-04-30

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00439933 on ClinicalTrials.gov