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Double Blind Crossover Comparison of Diuretics in the Young

NCT00429897 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2007-02-01

No results posted yet for this study

Summary

The principle objective of the study is to determine whether low-renin (i.e. salt sensitive) hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an over active salt pump in the kidney.

The kidneys have four different salt pumps, and each is blocked by a different type of diuretic (salt losing tablet)If one out of the four is overactive, we would expect patients to respond much better to one diuretic than to the alternatives - rather than responding equally well to all available types of diuretic.

Conditions

  • Low-Renin Hypertension

Interventions

DRUG

Bendroflumethiazide 2.5mg - 5mg

DRUG

Amiloride 20-40mg

DRUG

Spironolactone 50-100mg

DRUG

Frusemide 20-40mg

DRUG

Bendroflumethiazide 1.25-2.5mg/ Amiloride 10-20mg combined

Sponsors & Collaborators

Principal Investigators

  • Morris J Brown, Proffessor · Cambridge University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-08-31
Completion
2007-07-31

Countries

  • United Kingdom

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00429897 on ClinicalTrials.gov