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Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

NCT00415493 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2017-03-06

Study results available
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Summary

This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.

Conditions

  • Vasomotor Rhinitis

Interventions

OTHER

Cold-dry air provocation

15 minute exposure to cold-dry air by nasal mask

OTHER

Warm-moist air provocation

15 minute exposure to warm-moist air by nasal mask

Sponsors & Collaborators

Principal Investigators

  • Dennis Shusterman, MD, MPH · University of Washington

  • Stephen A Tilles,, MD · ASTHMA, Inc.

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-12-31
Primary Completion
2007-10-31
Completion
2008-05-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00415493 on ClinicalTrials.gov