National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children

Summary

The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to determine if genetic differences between the two groups contribute to causing the adverse drug reactions; and (3) to develop patient specific drug dosing guidelines to prevent future adverse drug reactions. We also wish to compare the use of prescription drugs, medical and hospital services and vital statistics between BC participants who experience adverse drug reactions and those who do not.

Study hypothesis: Genetic differences may contribute to patients' response to drugs and may be responsible for adverse drug reactions.

Conditions

• Adverse Drug Reaction (ADR)

Sponsors & Collaborators

• Genome Canada

  collaborator OTHER

• Genome British Columbia

  collaborator INDUSTRY

• Child and Family Research Institute

  collaborator OTHER

• Western University, Canada

  collaborator OTHER

• Provincial Health Services Authority British Columbia

  collaborator OTHER

• Health Canada

  collaborator OTHER_GOV

• Canada Gene Cure

  collaborator UNKNOWN

• Eli Lilly and Company

  collaborator INDUSTRY

• Pfizer

  collaborator INDUSTRY

• Merck Sharp & Dohme LLC

  collaborator INDUSTRY

• Canadian Society of Clinical Pharmacology

  collaborator UNKNOWN

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• Canada Foundation for Innovation

  collaborator OTHER

• British Columbia Clinical Genomics Network

  collaborator OTHER

• University of British Columbia

  lead OTHER

Principal Investigators

• Bruce Carleton, Pharm. D. · University of British Columbia

• Michael Hayden, MD, Ph.D · University of British Columbia

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2005-08-31

Primary Completion

2029-03-31

Completion

2029-03-31

Countries

• Canada

Study Locations