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Polymorphism of the Cytochrome P450-system in Renal Transplants

NCT00223054 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2011-08-04

No results posted yet for this study

Summary

In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance (MDR) gene in renal transplant patients to look for differences in dosing of immunosuppressive drugs (tacrolimus, sirolimus, everolimus, cyclosporine A).

All patients who receive one of these drugs can be included and drug blood trough levels, dosing and genetics are compared.

Conditions

  • Function of Renal Transplant

Interventions

DRUG

tacrolimus

retrospective analyze of drug levels in comparison to polymorphism

DRUG

sirolimus

retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism

DRUG

everolimus

retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism

DRUG

cyclosporin A

retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism

Sponsors & Collaborators

  • University of Kiel

    collaborator OTHER

  • University Hospital Schleswig-Holstein

    lead OTHER

Principal Investigators

  • Lutz Renders, MD · University of Schleswig-Holstein, Campus Kiel, Department of Nephrology

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-03-31
Primary Completion
2006-06-30
Completion
2006-10-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00223054 on ClinicalTrials.gov