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Determinants of Corticosteroid Insensitivity in Smokers With Asthma

NCT00411320 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 53

Last updated 2011-08-04

No results posted yet for this study

Summary

Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. The investigators will perform a number of blood \& breathing tests to try to discover the cause/s behind this phenomenon with the aim of producing leads for further investigation and possible new treatments for smokers with asthma.

Conditions

  • Asthma
  • Smoking
  • Steroid Resistance
  • Corticosteroid Insensitivity

Interventions

DRUG

oral steroid-dexamethasone

2 week steroid trial

Sponsors & Collaborators

  • Chief Scientist Office of the Scottish Government

    collaborator OTHER_GOV

  • University of Glasgow

    lead OTHER

Principal Investigators

  • Mark Spears, MRCP · University of Glasgow

  • Neil C Thomson, FRCP · University of Glasgow

  • Rekha Chaudhuri, MD · University of Glasgow

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2010-08-31
Completion
2010-09-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00411320 on ClinicalTrials.gov