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The Effects of Montelukast on Smokers With Asthma

NCT00712335 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 105

Last updated 2012-05-16

Study results available
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Summary

The purpose of this study is:

1. To compare neutrophilia, eosinophilic inflammatory markers and asthma symptom indices between smokers and non-smokers.
2. To elucidate the mechanism by which cigarette smokers are resistant to corticosteroids.

Conditions

  • Asthmatic Smokers
  • Non-asthmatic Smokers

Interventions

DRUG

Fluticasone Propionate

DPI 250 mcg BID for 3 weeks

DRUG

Montelukast

PO 10 mg QHS for 3 weeks

DRUG

Salmeterol

DPI 50mg BID for 3 weeks

Sponsors & Collaborators

  • Inje University

    lead OTHER

Principal Investigators

  • Chang-Keun Kim, MD, PhD · Asthma and Allergy Center, Inje University Sanggye Paik Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-02-28
Primary Completion
2011-05-31
Completion
2011-05-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00712335 on ClinicalTrials.gov