A Pharmacogenomic Study of Candesartan in Heart Failure
NCT00400582 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 300
Last updated 2011-07-22
Summary
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
Conditions
Interventions
- DRUG
-
Candesartan up to 32 mg daily
Candesartan 4 to 32 mg daily
Sponsors & Collaborators
- collaborator INDUSTRY
-
Montreal Heart Institute
lead OTHER
Principal Investigators
-
Michel White, MD · Montreal Heart Institute
-
Simon de Denus, B. Pharm, MSc,PhD · Montreal Heart Institute/ Faculty of Pharmacy, University of Montreal
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-11-30
- Primary Completion
- 2010-04-30
- Completion
- 2010-04-30
Countries
- Canada
Study Locations
More Related Trials
-
Candesartan in the Prevention of Relapsing Atrial Fibrillation
NCT00130975 ·Status: COMPLETED ·Phase: PHASE3
-
Candesartan and Candesartan/ Hydrochlorothiazide in the Treatment of Patients With Hypertension and LVH
NCT00607633 ·Status: COMPLETED
-
CKD-330 Drug-Drug Interaction Study (Candesartan)
NCT02064621 ·Status: COMPLETED ·Phase: PHASE1
-
The Potential of Candesartan to Retard the Progression of Aortic Stenosis
NCT00699452 ·Status: UNKNOWN ·Phase: PHASE3
-
CHANCE - Candesartan in Hypertrophic Cardiomyopathy
NCT00430833 ·Status: UNKNOWN ·Phase: PHASE2
-
The VALIDATE Study of Valsartan for Patients With Early Stage Heart Failure
NCT00241098 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan
NCT04991207 ·Status: COMPLETED ·Phase: PHASE1
-
A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
NCT03276598 ·Status: COMPLETED ·Phase: PHASE4
-
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker
NCT01444833 ·Status: UNKNOWN ·Phase: NA
-
A Clinical Study to Compare the Safety and Pharmacokinetics of CKD-320 and D012
NCT04035538 ·Status: UNKNOWN ·Phase: PHASE1
-
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/12.5 and 32/25 mg in Comparison With Candesartan 32 mg
NCT00383929 ·Status: COMPLETED ·Phase: PHASE3
-
The Renin-Angiotensin System in Essential Hypertension
NCT00141583 ·Status: TERMINATED ·Phase: NA
-
The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction
NCT00523549 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of Valsartan Administered Once Daily Versus Twice Daily, in Patients With Stable, Chronic Heart Failure
NCT00294086 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy
NCT05899920 ·Status: RECRUITING ·Phase: NA
-
Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
NCT02884206 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy of Candesartan on Reducing Blood Pressure in Insulin-Resistant, Obese Patients With Hypertension.
NCT00775814 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure
NCT00853658 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase 2 Dose Selection Trial of Candesartan Cilexetil and Amlodipine Besylate to Treat Essential Hypertension
NCT02059616 ·Status: UNKNOWN ·Phase: PHASE2
-
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo
NCT00434967 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy Observational Study of Candesartan Cilexetil on Hypertensive Patients
NCT00573742 ·Status: COMPLETED
-
Phase Ⅰ Study to Compare the Safety, Pharmacokinetic Profiles of CJ Amlodipine/Valsartan 10/160mg Tablet and Novartis Exforge 10/160mg Tablet
NCT01735890 ·Status: COMPLETED ·Phase: PHASE1
-
A Dose Selection Trial of CKD-330 in Patients With Essential Hypertension
NCT02206165 ·Status: UNKNOWN ·Phase: PHASE2
-
LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction
NCT00887588 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Azilsartan in Participants With Mild to Moderate Uncomplicated Essential Hypertension
NCT01289132 ·Status: COMPLETED ·Phase: PHASE2