Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
NCT00393562 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL
Last updated 2015-06-26
Summary
This is an open-label cross-over randomized control study comparing the effect of modafinil and methylphenidate in patients with Parkinson's disease with excessive daytime sleepiness.
Conditions
Interventions
- DRUG
-
modafinil
- DRUG
-
methylphenidate
Sponsors & Collaborators
-
US Department of Veterans Affairs
lead FED
Principal Investigators
-
Gabriel Bucurescu, MD MS · Philadelphia, OPC
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 50 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-03-31
- Primary Completion
- 2007-10-31
- Completion
- 2007-10-31
Countries
- United States
Study Locations
More Related Trials
-
PF 06412562 in Subjects With Advanced Stage Parkinson's Disease
NCT03665454 ·Status: COMPLETED ·Phase: PHASE1
-
The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease.
NCT01244269 ·Status: TERMINATED ·Phase: PHASE4
-
Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
NCT00526630 ·Status: COMPLETED ·Phase: PHASE4
-
Caffeine for Excessive Daytime Somnolence in Parkinson's Disease
NCT00459420 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Dose Range Finding Study of BF2.649 Versus Placebo to Treat Excessive Daytime Sleepiness in Parkinson's Disease Patients
NCT00642928 ·Status: COMPLETED ·Phase: PHASE2
-
Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease
NCT06356662 ·Status: RECRUITING ·Phase: PHASE1
-
A Trial to Compare the Efficacy of Rotigotine Transdermal Patch to That of Ropinirole on Early Morning Motor Impairment and Sleep Disorders in Subjects With Early-Stage, Idiopathic Parkinson's Disease
NCT00243971 ·Status: COMPLETED ·Phase: PHASE3
-
Study Evaluating Sumanirole for the Treatment of the Signs and Symptoms of Early Parkinson's Disease.
NCT00036218 ·Status: COMPLETED ·Phase: PHASE3
-
A Pharmacodynamics and Safety Study of DSP-9632P in Patients With Levodopa-Induced Dyskinesia in Parkinson's Disease
NCT05435729 ·Status: COMPLETED ·Phase: PHASE1
-
PF-06669571 In Subjects With Idiopathic Parkinson's Disease
NCT02565628 ·Status: COMPLETED ·Phase: PHASE1
-
Attention Modulation for Treatment of Parkinson's Disease and Dementia With Lewy Bodies
NCT01256905 ·Status: WITHDRAWN ·Phase: NA
-
Open Label Sumanirole Study of Safety, Tolerability, and Therapeutic Response In Patients With Parkinson's Disease
NCT00036205 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy, Safety And Tolerability Study In Subjects With Parkinson's Disease
NCT02006290 ·Status: COMPLETED ·Phase: PHASE1
-
Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)
NCT03083132 ·Status: COMPLETED ·Phase: PHASE2
-
A 4-Week Study of the Safety, Efficacy, and Pharmacokinetics of JZP-110 [(R)-2-amino-3-phenylpropylcarbamate Hydrochloride] in Subjects With Parkinson's Disease and Excessive Sleepiness
NCT03037203 ·Status: COMPLETED ·Phase: PHASE2
-
A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD
NCT05357989 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Three Doses of TCH346 in Patients With Early Parkinson's Disease to Evaluate Safety and Efficacy
NCT00407212 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Evaluation of the Efficacy and Safety of Bumetanide in Parkinson's Disease
NCT03899324 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease
NCT02074410 ·Status: TERMINATED ·Phase: PHASE2
-
Placebo Controlled Study of Preladenant in Participants With Moderate to Severe Parkinson's Disease (P07037)
NCT01227265 ·Status: COMPLETED ·Phase: PHASE3
-
Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine
NCT02365012 ·Status: UNKNOWN ·Phase: NA
-
The Role of Dopamine in Motor Learning in Healthy Subjects and Patients With Parkinson's Disease
NCT00032812 ·Status: COMPLETED
-
Study on the Safety, Tolerance and Pharmacokinetics of Phenlarmide Tablets
NCT04693039 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia
NCT01092065 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 in Subjects With Idiopathic Parkinson's Disease
NCT02373072 ·Status: COMPLETED ·Phase: PHASE1