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Effects of Two Anti-HIV Drug Regimens on HIV Transmission Risk Behavior Among SMART Study Participants

NCT00386035 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 883

Last updated 2014-04-17

No results posted yet for this study

Summary

The purpose of this study is to compare the effects of two different anti-HIV drug regimens on HIV transmission risk behavior among SMART study participants.

Conditions

  • HIV Infections

Interventions

DRUG

Delayed ART

Participants follow a drug conservation (DC) regimen in which ART is stopped or deferred until CD4 cell count dropped below 250 cells/mm3, initiated until CD4 cell count is at least 350 cells/mm3, and then are followed by episodic ART based on CD4 cell count.

DRUG

Continuous ART

Group 2 participants follow a viral suppression (VS) regimen in which ART was continued to keep viral loads as low as possible, regardless of CD4 cell count.

Sponsors & Collaborators

  • Community Programs for Clinical Research on AIDS

    collaborator NETWORK

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Wafaa El-Sadr, MD, MPH · Harlem AIDS Treatment Group, Harlem Hospital Center

  • James Neaton, PhD · CPCRA Statistical and Data Management Center/CCBR

Eligibility

Min Age
13 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-01-31
Primary Completion
2006-01-31
Completion
2008-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00386035 on ClinicalTrials.gov