Preventing Sexual Transmission of HIV With Anti-HIV Drugs

Summary

This study will determine whether anti-HIV drugs can prevent the sexual transmission of HIV among couples in which one partner is HIV infected and the other is not.

Conditions

• HIV Infections

Interventions

DRUG

Atazanavir

300 mg taken orally once daily

DRUG

Didanosine

400 mg taken orally once daily

DRUG

Efavirenz

600 mg taken orally once daily

DRUG

Emtricitabine/Tenofovir disoproxil fumarate

200 mg emtricitabine/ 300 mg tenofovir disoproxil fumarate tablet taken orally once daily

DRUG

Lamivudine

300 mg taken orally once daily

DRUG

Lopinavir/Ritonavir

200 mg lopinavir/ 50 mg ritonavir tablet taken orally once daily

DRUG

Nevirapine

200 mg taken orally once daily for 14 days followed by 200 mg taken orally twice daily

DRUG

Stavudine

Dosage depends on weight

DRUG

Tenofovir disoproxil fumarate

300 mg taken orally once daily

DRUG

Zidovudine/Lamivudine

150 mg lamivudine/ 300 mg zidovudine tablet taken orally twice daily

Sponsors & Collaborators

• HIV Prevention Trials Network

  collaborator NETWORK

• National Institute of Allergy and Infectious Diseases (NIAID)

  lead NIH

Principal Investigators

• Myron S. Cohen, MD · University of North Carolina, Chapel Hill

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2005-02-28

Primary Completion

2015-05-31

Completion

2015-05-31

Countries

• United States
• Botswana
• Brazil
• India
• Kenya
• Malawi
• South Africa
• Thailand
• Zimbabwe

Study Locations