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Safety and Accuracy of Alveoscopy in Interstitial Lung Diseases

NCT00377338 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 270

Last updated 2013-07-30

No results posted yet for this study

Summary

Fibered confocal fluorescence microscopy (FCFM), also referred to as Cell-Vizio® (MaunaKea Technologies, France) is a new technique that produces microscopic imaging in a living tissue, through a 1 mm fiberoptic miniprobe that can be introduced into the working channel of the bronchoscope. The system produces real-time imaging of endogenous fluorophores with a 5 µm lateral resolution and a field of view of 600 x 600 µm. FCFM is able to produce dynamic, high-resolution microimaging of the respiratory bronchiolar walls, alveolar ducts and sacs in vivo during endoscopy (a procedure termed as alveoscopy).

The hypothesis of this study is that an alveoscopy makes it possible to analyze the microstructure of the distal airways in vivo and to collect specific morphologic information in patients with interstitial lung diseases.

The goals of this French Phase II trial are:

* to evaluate the tolerance of the alveoscopy
* to describe the normal appearance of the bronchoalveolar system in spontaneous ventilation in normal subjects
* to describe specific alterations of the bronchoalveolar microstructure in focal or diffuse interstitial lung diseases

Conditions

  • Respiratory Tract Diseases

Sponsors & Collaborators

  • University Hospital, Rouen

    lead OTHER

Principal Investigators

  • Luc C Thiberville, MD · University Hospital, Rouen

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-05-31
Primary Completion
2013-06-30
Completion
2013-06-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00377338 on ClinicalTrials.gov